In the grapeseed extract studies below, the effectiveness of grapeseed extract is clearly shown and the benefits are enumerated. As processing of these extracts has improved, we believe future grapeseed extract studies will reflect even more promising results for natural health.
Grapeseed extract (grapeseed oil) is derived from whole grape seeds, and has a great concentration of vitamin E, flavonoids, linoleic acid, and OPCs (oligomerc procyanidolic complexes).
The quality of grapeseed extract depends on the manufacturing process as well as on the quality of the grapes, where they are from, the type of grape, and whether the whole grape seed is used or just the husk.
01 May 2006
Beneficial Effects of a Novel IH636 Grape Seed Proanthocyanidin Extract in the Treatment of Chronic Pancreatitis
Publication: Digestion 2001;63:203-206 (DOI: 10.1159/000051890)
Authors: Bhaskar Banerjee, Debasis Bagchi at Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St Louis, Mo., and Creighton University School of Pharmacy and Allied Health Professions, Omaha, Nebr., USA
Abstract: Oxygen-derived free radicals mediate tissue damage in acute and chronic pancreatitis. Low levels of natural antioxidants in pancreatitis indicate their increased utilization as scavengers of free radicals. Combination therapy with selenium, beta-carotene, methionine, and vitamins C and E are known to improve symptoms of chronic and recurrent pancreatitis. This, however, requires many tablets to be taken daily, which is impractical and may reduce compliance. Three patients with chronic pancreatitis (two with a history of alcohol excess and one idiopathic) are reported. Treatment with narcotic analgesics and pancreatic enzyme supplements had failed to control their symptoms. The addition of a commercially available IH636 grape seed proanthocyanidin extract (commercially known as ActiVin) to their treatment regimen led to a reduction in the frequency and intensity of abdominal pain as well as resolution of vomiting in 1 patient. Read complete article
22 December 2004
Proteomics Analysis of Rat Brain Protein Modulations by Grape Seed Extract
Publication: J. Agric. Food Chem., 2004, 52 (26), pp 7872–7883 DOI: 10.1021/jf040407d
Authors: Jessy Deshane at Department of Pharmacology and Toxicology, University of Alabama at Birmingham Comprehensive Cancer Center
Abstract: Health-food activists have long touted the value of taking grape seed extract. However, there has been little or no scientific evidence of the molecular basis for its benefits. Now, researchers at the University of Alabama at Birmingham (UAB) report the first direct evidence that the popular dietary supplement affects specific proteins in healthy brains in ways that may protect against future age-related dementia. Read news article here and read complete scientific article here.
27 February 2003
Molecular mechanisms of cardioprotection by a novel grape seed proanthocyanidin extract.
Publication: PubMed 2003 Feb-Mar;523-524:87-97.
Authors: Bagchi D, Sen CK at Department of Pharmacy Sciences, Medical Center, School of Pharmacy and Creighton University Health Professions, 2500 California Plaza, Omaha, NE
Abstract: Free radicals and oxidative stress play a crucial role in the pathophysiology of a broad spectrum of cardiovascular diseases including congestive heart failure, valvular heart disease, cardiomyopathy, hypertrophy, atherosclerosis and ischemic heart disease. Read complete article
20 Novermber 2002
Grape Seed Proanthocyanidins Prevent Plasma Postprandial Oxidative Stress in Humans
Publication: J. Agric. Food Chem., 2002, 50 (26), pp 7720–7725 DOI: 10.1021/jf020346o
Authors: Fausta Natella at Free Radical Research Group, National Research Institute for Food and Nutrition, INRAN, Via Ardeatina 546, 00178 Rome, Italy
Abstract: The present study was designed to investigate the effect of supplementing a meal with grape seed proanthocyanidins (the main phenolic antioxidant of red wine) on plasma postprandial oxidative stress. Read complete article